0000006393 00000 n The AstraZeneca vaccine has been made from a modified adenovirus which causes the common cold in chimpanzees, but specifically modified so that it cannot cause an infection. The second injection can be given between 4 and 12 weeks after the first injection. 0000024916 00000 n This webpage was updated on 16 March 2022 to reflect the latest guidance and ensure consistency of information and formatting. Talk to the healthcare provider if you have questions. Some excipients are added to a vaccine for a specific purpose. Active ingredients Added ingredients Products used in the manufacture of the vaccine Growing the active ingredients Further information The information on this page is based on the best information that we can find from the available literature. 0000000016 00000 n 0000004124 00000 n 2020 has been a difficult year for all, but has seen 58 vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) be developed and in clinical trials,1 with some vaccines reportedly having more than 90% efficacy against COVID-19 in clinical trials. Seek immediate medical attention if you develop weakness and paralysis in the extremities that are persistent and can affect both sides of the body at the same time and can progress to the chest and face (Guillain-Barr Syndrome). Overall, among the participants who received COVID-19 Vaccine AstraZeneca, 90.3% were aged 18 to 64 years and 9.7% were 65 years of age or older. py]IioB^;+q/u_q^okl@ 0s7(-e?rbBS\Lg!-,p77cicd@&( This is not enough to cause any noticeable effects. LYpeP4 &=C&CBzLL3y20gah!A '1>ederj4+e@Zg Rc`TaPa`2R6r G2p T 0000008003 00000 n << /Linearized 1 /L 149707 /H [ 2229 301 ] /O 59 /E 79897 /N 11 /T 149221 >> endobj WHO recommends focusing on achieving high first dose coverage by extending the inter-dose interval, whilst continuing to maximize second dose coverage of vulnerable groups in the context of variants of concern. In this vaccine ,polysorbate 80 works to separate the listed ingredient of water from other oil-based ingredients. /Root 55 0 R assess the risks and benefits taking into consideration their epidemiological situation. Some cases were life-threatening or had a fatal outcome. The expiry date refers to the last day of that month. Oxford-AstraZeneca COVID-19 vaccine efficacy. According to the information that AstraZeneca and the University of Oxford presented to the United Kingdom's vaccine regulatory agency, this vaccine contains: The vaccine does not include any human or animal products, thimerosal, gelatin, or formaldehyde. No data are currently available on the use of COVID-19 Vaccine AstraZeneca in children and adolescents younger than 18 years of age. Some of the information might be out of date or no longer relevant. endstream endobj 73 0 obj <>/Font<>/ProcSet[/PDF /Text /ImageB /ImageC /ImageI]/XObject<>>>/Rotate 0/Type/Page>> endobj 74 0 obj <> stream We also use cookies set by other sites to help us deliver content from their services. It is a proven, safe and relatively old approach. Published March 31, 2021 Updated Aug. 1, 2021. 0000005745 00000 n 0000132021 00000 n It should be noted that the full two The Oxford-AstraZeneca vaccine contains no pork products or by-products. 779 0 obj <> endobj endobj Title: Redirect for COVID-19 AstraZeneca Vaccine EUA Fact Sheet for Recipients Author: CDC/NCIRD Subject: The results confirmed a single dose of AZD1222 resulted in a four-fold increase in antibodies to the SARS-CoV-2 virus spike protein in 95% of participants one month after injection. AstraZeneca's vaccine contains a chimpanzee adenovirus genetically engineered to avoid its replication and instead make Covid spike protein in people receiving the jab. endstream endobj 76 0 obj <> stream 0000006047 00000 n brain, liver, bowel, spleen). 0000001096 00000 n No serious adverse events were reported with AZD1222, and reactions were lessened with the use of prophylactic paracetamol. Any unused vaccine or waste material should be disposed of in accordance with local requirements. To help pregnant women make this assessment, they should be provided with Do not use COVID-19 Vaccine AstraZeneca after the expiry date which is stated on the label after EXP. 0000003094 00000 n After COVID-19 immunization, it takes a few weeks for the body to build immunity so that you are protected from the virus. The average age of those who have experienced severe allergic reactions so far is . 0000006792 00000 n CLS is a serious, potentially fatal condition causing fluid leakage from small blood vessels (capillaries) resulting in rapid swelling of the arms and legs, sudden weight gain and feeling faint (low blood pressure). The vaccine does not contain any preservative and should be administered by a healthcare professional. When autocomplete results are available use up and down arrows to review and enter to select. 55 0 obj Of those who experienced fever, 18% reported temperatures of at least 38C, and 2% reported temperatures of at least 39C. 56 0 obj AZD1222 FDA Approval Status. Very low levels of blood platelets (immune thrombocytopenia), that can be associated with bleeding, have been reported very rarely, usually within the first four weeks following vaccination with COVID-19 Vaccine AstraZeneca. We comply with the HONcode standard for trustworthy health information. 0000019840 00000 n Excipients are the non-active ingredients that are added to the vaccine for a variety of reasons. x]n@@eH%/Vu1]}sn\H6:ypen^mVU}m)QmB9ciMeT{ed#NtQwv/ ,6aYmk}*Oko8/q1(z h^ONc! People with a history of severe allergic reaction to any component of the vaccine should not take it. xVN@}W#E{I HTJB+!`)m;:KQyX99se LqIai8O=,*EM~|>0: NiV|+'#M(FYQc`uic+)Gy1Q(:'4~0:,9Dbdf&. %PDF-1.6 % Well send you a link to a feedback form. It uses a dead version of the SARS -CoV-2 virus so that it cannot replicate, but it keeps the surface spike protein intact to trigger the body's immune system. All 28 developed different types of clots, or thromboses, five to 16 days after vaccination, and all had made antibodies against platelets. Moderna COVID-19 vaccine. It is a summary of information about the drug and will not tell you everything about the drug. How to store COVID-19 Vaccine AstraZeneca 6. 803 0 obj <>/Filter/FlateDecode/ID[<2F70D35E7B8A59458B52A8ED8203A71C><24F7C9D4F005C249BEA4CA3B57A534AF>]/Index[779 189]/Info 778 0 R/Length 129/Prev 229930/Root 780 0 R/Size 968/Type/XRef/W[1 3 1]>>stream 0000004537 00000 n ____________________________________________________________________________________. A respiratory syncytial virus vaccine or RSV vaccine is a vaccine which prevents infection by respiratory syncytial virus.As of 2023, no licensed vaccine against RSV exists.. 0000102287 00000 n News stories, speeches, letters and notices, Reports, analysis and official statistics, Data, Freedom of Information releases and corporate reports. You may need to read it again. syndrome [GBS]), rapid swelling under the skin in areas such as the face, lips, mouth and throat (which may cause difficulty in swallowing or breathing) (angioedema), capillary leak syndrome (a condition causing fluid leakage from small blood vessels), very low levels of blood platelets (immune thrombocytopenia) that can be associated with bleeding (see section 2, Blood disorders), blood clots in the brain, not associated with low level of blood platelets (see section 2, Blood disorders), inflammation of the spinal cord which may cause muscle weakness, localised or radiating back pain, bladder and bowel symptoms and changes in sensation (transverse myelitis). If you are not sure, talk to your doctor, pharmacist or nurse. The need for, and timing of, booster doses for children aged 5-11 years has not yet been determined. 0000098057 00000 n 0000007733 00000 n (Centers for Disease Control and Prevention). 0000014217 00000 n Vaccines, by Vaccine In addition to weakened or killed disease antigens (such as weakened, killed, or parts of viruses or bacteria), vaccines contain very small amounts of other ingredients - excipients. This includes any possible side effects not listed in this leaflet. The majority of these cases occurred within the first 3 weeks following vaccination but some have also been reported after this period. 0000088968 00000 n 0000002028 00000 n Ingredients in the Pfizer-BioNTech Comirnaty COVID-19 vaccine. If you are immunocompromised and receive a third dose of COVID-19 Vaccine AstraZeneca, it may still not provide full immunity to COVID-19 and you should continue to maintain physical precautions to help prevent COVID-19. 3. Keep this medicine out of the sight and reach of children. The Oxford-AstraZeneca vaccine is cheaper and easier to transport and store than some of the other vaccines approved for use to date and as such, was going to play a key part in combating the . Once the vaccine has undergone Phase 3 testing, the manufacturer can apply for a license from regulatory authorities (like the FDA in the US) to make the vaccine available for public use. information about the risks of COVID-19 in pregnancy, the likely benefits of vaccination in the local epidemiological context, and the current limitations of safety data in pregnant women. 0000015824 00000 n Explanation of ingredients: - mRNA: Like the Pfzer BioNTech vaccine, Moderna's also uses mRNA technology to build antibodies against COVID-19. This webpage was updated on 5 January 2022 to update the latest guidance and ensure consistency of information and formatting. Consumer Information. This Oxford-AstraZeneca vaccine uses the ChAdOx1 technology, which has been developed and optimised by the Jenner Institute over the last 10 years. The Oxford-AstraZeneca vaccine contains no thimerosal, mercury, or aluminum. If you forget to go back at the scheduled time, ask your doctor, pharmacist or nurse for advice. No substantive data are available related to impact of the vaccine on transmission or viral shedding. What COVID-19 Vaccine AstraZeneca is and what it is used for COVID-19 Vaccine AstraZeneca is a vaccine used for preventing COVID-19, caused by a virus called coronavirus (SARS-CoV-2). Discard the vial and do not combine residual vaccine from multiple vials. 0000132090 00000 n SARS-CoV-2 transmission, the benefit of vaccination in protecting against COVID-19 far outweighs the risks. The COVID-19 vaccines currently approved for use in the UK are: Moderna (Spikevax) Pfizer/BioNTech (Comirnaty) Novavax (Nuvaxovid) AstraZeneca (Oxford) (not available) Janssen (Johnson & Johnson) (not available) Valneva (Valneva) (not available) Which vaccine will I get? 0000107040 00000 n Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. {zzZ`ntK?D6r|D#T$* TGBKz. The last nine ingredients on the list are called 'excipients.' This is the same type of vaccine that flu and the Middle East Respiratory Syndrome vaccines have used for years. If you have a previous diagnosis of capillary leak syndrome (a condition causing fluid leakage from small blood vessels). Netherlands. trailer These ingredients range from forms of salt that help preserve the vaccine to water that dilutes it into the right concentration. Each vial contains 8 doses of 0.5 ml. (see section 2. The overall safety of COVID-19 Vaccine AstraZeneca is based on an interim analysis of pooled data from four clinical trials conducted in the United Kingdom, Brazil, and South Africa. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. @A20;ia p9I2mL1-bt.S\3=!c`j= y&f" 0M %PDF-1.7 % 0000025064 00000 n When COVID-19 Vaccine AstraZeneca is given for the first injection, the second injection to complete the vaccination course should also be with COVID-19 Vaccine AstraZeneca. Pharmaceutical giant AstraZeneca and its partner Oxford University released preliminary results from its phase 3 Covid-19 vaccine trials on Monday, which found that the company's vaccine,. Once it is approved for human research, there are three phases that take place before the vaccine can be considered for approval for public use. This poses a challenge, because some novelty is needed to make sure our bodies don't mistake the vaccine for a virus we are already know how to fight. Generic name: SARS-CoV-2 vaccine 581 0 obj <>stream Store in a refrigerator (2C to 8C). Read all of this leaflet carefully before the vaccine is given because it contains important information for you. Function. 0000006540 00000 n endstream request information about a specific topic, United Kingdom Medicines & Healthcare products Regulatory Agency, University of Oxford Vaccine Knowledge Project, United States Centers for Disease Control and Prevention, A weakened adenovirus, which delivers the the COVID-19 spike glycoprotein (this is the active ingredient; also called the 'antigen'), L-histidine hydrochloride monohydrate (amino acid), Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial (, A Novel Chimpanzee Adenovirus Vector with Low Human Seroprevalence: Improved Systems for Vector Derivation and Comparative Immunogenicity (, Adenoviral vectors are the new COVID-19 vaccine front-runners. Prophylactic paracetamol or viral shedding the Oxford-AstraZeneca vaccine contains no thimerosal, mercury, or aluminum a of... 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